Innovations and research
in the field of immunology

An immune system is the earliest, highly sensitive indicator of almost any pathological processes in the body and of diseases, poisoning, overload, various injuries, including mental, dystrophy, exhaustion, aging, etc.

The immune system functions in case of infectious diseases and recognized pathogens, as it eliminates them and creates immunity. It not only provides protection against germs, viruses, protozoa, but also, the formation of immunity protects against many substances that are foreign to the body, self-non-self-discrimination, preservation of genetic individuality, rejection of foreign tissues, cancer control,
and elimination of the dead and obsolete cells (including those infected with viruses) through the mechanism of apoptosis.

At the present stage, the immune system can be regarded as integrative, since it is integrated into almost all other systems of the body and performs a complex of “immune“ and “non-immune“ functions. Thus, it “works“ in controlling inflammation, and the inflammatory response is an essential component of the immune response, without which it is impossible. The immune system plays a key role in the metabolism of fats, proteins and nucleic acids, iron, in blood coagulation and fibrinolysis, in regulating growth and morphogenesis, cellular and bone regeneration, osteogenesis, and is involved in the process of the gastrointestinal tract and maintaining the composition of normal intestinal microflora. That is why the violation of the composition of this microflora is accompanied by impaired immunity and the development of severe pathology, and the restoration of the normal composition of the microflora leads to the elimination of immune deficiencies.

The immune system is very closely related to the nervous and endocrine (hormonal) systems. For this reason, the cellular bioactive substances produced by the immune system activate the nerve cells of the pituitary, hypothalamus and adrenal glands, while the central nervous system itself is able to form most of the bioactive products of the immune system, which also activate it. Receptors for the most of hormones are found on the membrane of immune cells, and the cells themselves can also form them. In turn, immune mediators can cause the formation of many hormones, neurotransmitters, and affect their activity.

A clear innervation of the organs of the immune system, the function of which is severely violated when nerves are damaged, the dependence of immune reactions on conditioned reflex activity, the relation of intellectual memory with immune competent cells, the damage of which causes instant loss of memory and stable conditioned reflexes, were established. Receptors to many mediators of the immune system has been found on the cells of the nervous system, and the removal of the central
immune organ, the thymus, causes atrophy of the pituitary cells, a sharp disturbance in the formation of many of the most important hormones, etc. At the same time, the greater part of hormones has an expressed effect on the activity of immune competent cells of the body.

Thus, the interaction of the immune, nervous and endocrine systems and the coordinated work of such complex in the body are irrefutably proven. It is facilitated by the fact that the blood-brain barrier, as it turns out, is permeable to mediators of the immune system and the immune competent cells themselves.

Through these substances, the effect on metabolism, the transport of various biologically active substances, changes in membranes, the multiplication of lymphoid cells, the synthesis of mediators of the immune system, and the regulating effect on the cells of endocrine, central nervous and other systems is performed. There is also a biochemical mechanism that ensures the unity of these three systems, including through the system of cyclic nucleotides (cAMP and cGMP).

That is why any changes in other systems will immediately have an effect on the state of the closely related immune system, and a wide range of almost all immune modulators that correct immune disorders and normalize the metabolism and functions of other organs and systems is explained by such interrelations.

Based on the integral concept, it becomes clear that in almost all pathological processes in the body — acute and chronic infections and somatic diseases, inflammations, organic lesions, surgical and mental injuries, intoxications and poisonings, dystrophies, aging, physical and mental overloads — immune system disorders, immunodeficiency states, always arise. In this sense, in terms of
diagnostics, our research and development company had accumulated a substantial amount of materials, including results from our own original work, and it is actually possible to establish a health disorder very early in the immune analysis and restore them. We should not forget that immune monitoring is also the earliest and most sensitive monitoring of the state of human health and the repair of its damage.

Another consideration is fundamentally important when developing new innovative approaches in medicine based on a new, yet not universally recognized, scientific paradigm. In vivo and in vitro immune models are the most convenient, easily reproducible and instrumentally controlled. They are very objective and adequate, and therefore allow to extrapolate the data obtained to the human body. Thus, there is every reason to believe that without the analysis of immune disorders, their correction,
modern treatment of diseases, as well as the debilitating effects on the body of stress, overloads, extreme effects, etc., cannot be considered as qualified.

All this makes our company’s management set a high value on the immune research and apply it to development of inventions, innovations, and new patents.